Effect of subinhibitory concentrations of antibiotics on mutation frequency in Streptococcus pneumoniae
نویسندگان
چکیده
منابع مشابه
Effect of subinhibitory concentrations of antibiotics on mutation frequency in Streptococcus pneumoniae.
OBJECTIVES To investigate the effect of subinhibitory concentrations of ciprofloxacin, streptomycin, trimethoprim, ampicillin and erythromycin on mutation frequency in Streptococcus pneumoniae. METHODS Frequency of mutation to rifampicin resistance was determined in three clinical isolates grown with or without antibiotic treatment. dinB was analysed using PCR and DNA sequence determination. ...
متن کاملSubinhibitory concentrations of penicillin increase the mutation rate to optochin resistance in Streptococcus pneumoniae.
OBJECTIVES The aim of this work was to study the effect of subinhibitory concentrations of penicillin, chloramphenicol and erythromycin on the mutation rate of Streptococcus pneumoniae. METHODS The mutation rate to rifampicin and optochin resistance was estimated using fluctuation analysis in three capsulated S. pneumoniae strains, cultured both with and without different subinhibitory antibi...
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ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 2006
ISSN: 1460-2091,0305-7453
DOI: 10.1093/jac/dkl064