Effect of subinhibitory concentrations of antibiotics on mutation frequency in Streptococcus pneumoniae

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Effect of subinhibitory concentrations of antibiotics on mutation frequency in Streptococcus pneumoniae.

OBJECTIVES To investigate the effect of subinhibitory concentrations of ciprofloxacin, streptomycin, trimethoprim, ampicillin and erythromycin on mutation frequency in Streptococcus pneumoniae. METHODS Frequency of mutation to rifampicin resistance was determined in three clinical isolates grown with or without antibiotic treatment. dinB was analysed using PCR and DNA sequence determination. ...

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ژورنال

عنوان ژورنال: Journal of Antimicrobial Chemotherapy

سال: 2006

ISSN: 1460-2091,0305-7453

DOI: 10.1093/jac/dkl064